Bioprocessing osmometers
Built for development and manufacturing workflows, our bioprocessing osmometers feature customer-centric technology that help deliver accurate and consistent titer, yield, purity and quality across biopharmaceutical, eye care, food & beverage and research environments.
Key features
Performance
Our complete OsmoTECH® osmometer range delivers fast, high-precision measurements using freezing point depression technology.
Each osmometer is factory calibrated with a minimum of two points, requiring minimal testing with only a quick check using Advanced Instruments® Clinitrol™ 290 before routine use.
Designed for intuitive operation
Our osmometers boast an intuitive design that minimizes manual intervention and shortens learning curves, ensuring rapid, error-free testing in high-pressure manufacturing environments.
Scalable
Shaped by customer insight, our OsmoTECH portfolio understands the demands of today’s complex, multi-stage biotechnology workflows and their diverse requirements.
Our osmometers are scalable across workflows and integrate easily to meet dynamic environments and requirements across process development and manufacturing.
Data management
Built to support strong data integrity practices, ensuring accurate, compliant, traceable and secure results in GMP environments throughout its lifecycle to help meet regulatory standards.
Compliance
Built for use in regulated bioprocessing environments, all models are GMP-compliant.
Service offerings
Our engineers are certified to perform IQ/OQ (Installation Qualification and Operational Qualification) services on our bioprocessing osmometers to support GMP compliance in your laboratory.
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Freezing point depression osmometers are the industry-preferred solution across clinical, biotechnology and pharmaceutical laboratories. Due to their proven accuracy and reliability across diverse sample types, they are a widely trusted and referenced method for osmolality testing.
Freezing point depression is a phenomenon where a liquid’s (solvent) freezing point is lowered when a solute is dissolved in it. This effect is measured by freezing point depression osmometers to determine osmolality.
Learn more about Freezing Point Depression Theory here.
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Osmolality plays a critical role across biopharmaceutical, cell and gene therapy, vaccine, and biologics manufacturing, where controlling the concentration of dissolved solutes is essential for cell performance and product quality.
It is monitored at various stages, including throughout media preparation, upstream cell culture and fermentation, downstream processing, and formulation. This is to help maintain optimal cell conditions, protect product integrity, and ensure consistent, scalable production.
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An osmometer can be used to analyse a variety of samples in the bioprocessing workflow and is critical for ensuring product quality, stability and process control. Common sample types include:
Cell Line Development
Media Development
Cell Culture
Buffer Development
Purification
Filtration
Formulation
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Advanced Instrument’s bioprocessing osmometers are designed to support GMP regulated environments by promoting secure, traceable, and controlled data management.
As such, the OsmoTECH range features robust built-in compliance tools, including audit trails, electronic signatures, user access control and data security.
Together with the IQ/OQ services and comprehensive documentation that our team of engineers are certified to provide, these capabilities support audit readiness and regulatory confidence throughout development and manufacturing workflows.
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Some important key factors for consideration are:
Sample type compatibility
Sample volume
Throughput needs
Level of automation and connectivity required
Regulatory requirements
Data integrity features
All osmometers are available with end-to-end, attentive customer care service.
End-to-end service
We provide consultations to help you choose the right osmometer and design a system that maximises productivity, so you can be confident with your lab’s workflow.
Industry-specific knowledge
We bring extensive knowledge across a wide range of industries, with decades of experience. We’ll tailor our service based on your industry.